"Actor/comedian Bernie Mac passed away this morning from complications due to pneumonia in a Chicago area hospital," his publicist, Danica Smith, said in a statement from Los Angeles.
She said no other details were available and asked that his family's privacy be respected.
The comedian suffered from sarcoidosis, an inflammatory lung disease that produces tiny lumps of cells in the body's organs, but had said the condition went into remission in 2005. He recently was hospitalized and treated for pneumonia, which his publicist said was not related to the disease.
Mac was born Bernard Jeffrey McCullough on Oct. 5, 1957, in Chicago. He grew up on the city's South Side, living with his mother and grandparents. His grandfather was the deacon of a Baptist church.
Mac worked his way to Hollywood success from an impoverished upbringing on Chicago's South Side. He began doing standup as a child, and his film career started with a small role as a club doorman in the Damon Wayans comedy "Mo' Money" in 1992. In 1996, he appeared in the Spike Lee drama "Get on the Bus."
He was one of "The Original Kings of Comedy" in the 2000 documentary of that title that brought a new generation of black standup comedy stars to a wider audience.
Mac went on to star in the hugely popular "Ocean's Eleven" franchise with Brad Pitt and George Clooney.
His turn with Ashton Kutcher in 2005's "Guess Who" topped the box office. It was a comedy remake of the classic Spencer Tracy and Katharine Hepburn drama "Guess Who's Coming to Dinner?" — with Mac as the black dad who's shocked that his daughter is marrying a white man.
Mac also had starring roles in "Bad Santa," "Charlie's Angels: Full Throttle" and "Transformers."
In the late 1990s, he had a recurring role in "Moesha," the UPN network comedy starring pop star Brandy.
The comedian drew critical and popular acclaim with his Fox television series "The Bernie Mac Show," which aired more than 100 episodes from 2001 to 2006.